Biliana Todorova

Biliana is a Postdoctoral researcher in the Unit of Antibodies in Therapy and Pathology at Institut Pasteur in Paris. She works on in vivo imaging of the anaphylactic reaction in preclinical models.

She did her PhD in the Immuno-Virology Division at the Atomic Energy Commission (CEA) in France. Under the supervision of Dr Roger Le Grand and Dr Catherine Chapon, she worked on the development of innovative in vivo imaging approaches for the visualization of the immune cell behavior in non-human primates. The main objective of her thesis was to describe early immune events that occur in the skin, after DNA vaccination associated to local electroporation. To reach her goal, she used fiber-based confocal microscopy to image cutaneous dendritic cells in a noninvasive manner and performed time-lapse laser-scanning confocal microscopy on skin biopsies to investigate the dynamic parameters of cell mobility and interactions. In addition, Magnetic Resonance Imaging (MRI) was used to visualize the popliteal lymph node after intradermal injection of iron oxide nanoparticles.

She started her postdoc in the team of Dr Pierre Bruhns, which has recently highlighted the mechanism of induction of the active anaphylaxis in the mouse involving the IgG receptors, the neutrophils and the platelet activating factor (PAF). They aim to develop in vivo imaging approaches to visualize anaphylactic reactions in real time. Thus whole body bioluminescence and fluorescence imaging will be associated to intravital microscopy to study the behavior of various immune cell populations during allergic shock.

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